A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation-Reference-Cited by-同舟云学术

A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation

Published:2020 Issue:2 Volume:5 Page:300-307
ISSN:2058-9883
Container-title:Reaction Chemistry & Engineering
language:en
Short-container-title:React. Chem. Eng.

Author:

Mancino Valentina¹²³⁴⁵,Croci Federico¹²³⁴⁵,Lozza Anna Maria¹²³⁴⁵,Cerra Bruno¹²³⁴⁵^ORCID,Gioiello Antimo¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Medicinal and Advanced Synthetic Chemistry (Lab MASC)

2. Department of Pharmaceutical Sciences

3. University of Perugia

4. 06122 Perugia

5. Italy

Abstract

The potential of integrating flow synthesizers, statistical design of experiments and automation has been exemplified to realize the streamlined etherification of pregnenolone to the neurosteroid 3β-methoxypregnenolone (MAP4343).

Funder

Fondazione Cassa di Risparmio di Perugia

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/RE/C9RE00353C

Reference43 articles.

1. Autonomous Discovery in the Chemical Sciences Part I: Progress

2. Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry

3. Automating drug discovery

4. The Molecular Industrial Revolution: Automated Synthesis of Small Molecules

5. Automated platforms for reaction self-optimization in flow

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