Identification and genotoxicity evaluation of two carbamate impurities in rasagiline-Reference-Cited by-同舟云学术

Identification and genotoxicity evaluation of two carbamate impurities in rasagiline

Published:2016 Issue:108 Volume:6 Page:106268-106274
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sun Yongqiang¹²³,Zhang Xinyu⁴⁵⁶³,Yan Yimin¹²³,Tu Yongrui¹²³,Feng Xiaohui¹²³,Jiang Wei¹²³,Zheng Feng⁴⁵⁶³⁷^ORCID

Affiliation:

1. Changzhou No.4 Pharmaceutical Co., Ltd

2. Changzhou 213004

3. China

4. Department of Pharmaceutical Analysis

5. China Pharmaceutical University

6. Nanjing 210009

7. Key Laboratory of Drug Quality Control and Pharmacovigilance

Abstract

During the synthesis of a second-generation monoamine oxidase-B inhibitor rasagiline, two unknown impurities (impurity A and impurity B) were detected and isolated by preparative liquid chromatography.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA20810J

Reference24 articles.

1. Rasagiline: A second-generation monoamine oxidase type-B inhibitor for the treatment of Parkinson’s disease

2. Rasagiline in Parkinson's disease: A review based on meta-analysis of clinical data

3. Cardiovascular activity of rasagiline, a selective and potent inhibitor of mitochondrial monoamine oxidase B: comparison with selegiline

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