Total synthesis of the natural product EBC-329-Reference-Cited by-同舟云学术

Total synthesis of the natural product EBC-329

Published:2015 Issue:36 Volume:13 Page:9485-9491
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Thombal Raju S.¹²³⁴,Jadhav Vrushali H.¹²³⁴

Affiliation:

1. Division of Organic Chemistry

2. National Chemical Laboratory (CSIR-NCL)

3. Pune-411008

4. India

Abstract

The first total synthesis of an anti-leukemic diterpene natural product EBC-329 (1) has been accomplished starting from readily available 6,6-dimethyl-3-oxabicyclo[3.1.0]hexane-2,4-dione (7). An efficient and general approach has been reported for the synthesis of EBC-329 in 13 steps with an overall yield of 10%.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C5OB01276G

Reference20 articles.

1. Croton insularis introduces the seco-casbane class with EBC-329 and the first casbane endoperoxide EBC-324

2. EBC-219: A New Diterpene Skeleton, Crotinsulidane, from the Australian Rainforest Containing a Bridgehead Double Bond

3. Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)

4. New Casbane Diterpenoids from a South China Sea Soft Coral, Sinularia sp.

5. Antimicrobial and antibiofilm action of Casbane Diterpene from Croton nepetaefolius against oral bacteria

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