Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors-Reference-Cited by-同舟云学术

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Published:2016 Issue:8 Volume:14 Page:2537-2549
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

De Vreese Rob¹²³⁴⁵,Depetter Yves¹²³⁴⁵,Verhaeghe Tom⁶²³⁴⁵,Desmet Tom⁶²³⁴⁵,Benoy Veronick⁷⁸⁹⁵,Haeck Wanda⁷⁸⁹⁵,Van Den Bosch Ludo⁷⁸⁹⁵,D′hooghe Matthias¹²³⁴⁵

Affiliation:

1. SynBioC Research Group

2. Faculty of Bioscience Engineering

3. Ghent University

4. B-9000 Ghent

5. Belgium

6. Centre for Industrial Biotechnology and Biocatalysis

7. Laboratory of Neurobiology and Vesalius Research Center (VIB)

8. Research Institute for Neuroscience and Disease (LIND)

9. KU Leuven

Abstract

Hydroxamic acids 2c, 2d and 3i-m represent valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors.

Funder

ALS Therapy Alliance

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02625C

Reference27 articles.

1. Epigenetic protein families: a new frontier for drug discovery

2. Histone deacetylases (HDACs): characterization of the classical HDAC family

3. Acetylation site specificities of lysine deacetylase inhibitors in human cells

4. The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

5. Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives

Cited by 25 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Heterocycles–Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years;ChemMedChem;2024-08-29

2. Development of a tetrahydroindazolone-based HDAC6 inhibitor with in-vivo anti-arthritic activity;Bioorganic & Medicinal Chemistry;2024-02

3. Update on thiopyran-fused heterocycle synthesis (2013–2024);Organic & Biomolecular Chemistry;2024

4. Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties;Journal of Chemistry;2022-05-19

5. Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy: screening, synthesis, and biological evaluation;Chemical Communications;2022