Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors-Reference-Cited by-同舟云学术

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Synthesis of inositol phosphate-based competitive antagonists of inositol 1,4,5-trisphosphate receptors

Published:2016 Issue:8 Volume:14 Page:2504-2514
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Konieczny Vera¹²³,Stefanakis John. G.⁴⁵⁶⁷⁸,Sitsanidis Efstratios D.⁴⁵⁶⁷⁸,Ioannidou Natalia-Anastasia T.⁴⁵⁶⁷⁸,Papadopoulos Nikolaos V.⁴⁵⁶⁷⁸,Fylaktakidou Konstantina C.⁹¹⁰¹¹¹²¹³,Taylor Colin W.¹²³,Koumbis Alexandros E.⁴⁵⁶⁷⁸

Affiliation:

1. Department of Pharmacology

2. Cambridge

3. UK

4. Laboratory of Organic Chemistry

5. Chemistry Department

6. Aristotle University of Thessaloniki

7. 54124 Thessaloniki

8. Greece

9. Laboratory of Organic

10. Bioorganic and Natural Product Chemistry

11. Molecular Biology and Genetics Department

12. Democritus University of Thrace

13. 68100 Alexandroupolis

Abstract

Potent competitive antagonists of the IP₃ receptors, through which Ca²⁺ is released in mammalian cells, are synthesized and characterized.

Funder

Wellcome Trust

German Academic Exchange Service

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB02623G

Reference47 articles.

1. Inositol Trisphosphate Receptor Ca2+ Release Channels

2. IP3 Receptors: Toward Understanding Their Activation

3. Calcium signalling: dynamics, homeostasis and remodelling

4. New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor

5. Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor

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1. Tricyclic systems: Central Carbon Ring With Fused Six-Membered Rings;Comprehensive Heterocyclic Chemistry IV;2022

2. Astrocytic IP3Rs: Beyond IP3R2;Frontiers in Cellular Neuroscience;2021-07-30

3. Inositol Adenophostin: Convergent Synthesis of a Potent Agonist of d-myo-Inositol 1,4,5-Trisphosphate Receptors;ACS Omega;2020-10-28

4. Both d- and l-Glucose Polyphosphates Mimic d-myo-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins(1,4,5)P3 Receptor;Journal of Medicinal Chemistry;2020-04-14

5. Synthesis of dimeric analogs of adenophostin A that potently evoke Ca2+release through IP3receptors;RSC Advances;2016

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