Amelioration of gold nanoparticles mediated through Ocimum oil extracts induces reactive oxygen species and mitochondrial instability against MCF-7 breast carcinoma

Author:

Mohanta Yugal Kishore12ORCID,Biswas Kunal3,Mishra Awdhesh Kumar4,Patra Biswajit5,Mishra Bishwambhar6ORCID,Panda Jibanjyoti1,Avula Satya Kumar7ORCID,Varma Rajender S.8ORCID,Panda Bibhu Prasad9ORCID,Nayak Debasis10

Affiliation:

1. Nano-biotechnology and Translational Knowledge Laboratory, Department of Applied Biology, School of Biological Sciences, University of Science and Technology Meghalaya, Techno City, 9th Mile, Baridua, Ri-Bhoi 793101, Meghalaya, India

2. Centre for Herbal Pharmacology and Environmental Sustainability, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam 603103, Tamil Nadu, India

3. Centre for Nanoscience & Nanotechnology International Research Centre, Sathyabama Institute of Science and Technology, Jeppiaar Nagar, Rajiv Gandhi Salai, Chennai 600119, India

4. Department of Biotechnology, Yeungnam University, Gyeongsan 38541, South Korea

5. Department of Botany, Fakir Mohan University, Balasore 756020, Odisha, India

6. Department of Biotechnology, Chaitanya Bharathi Institute of Technology (CBIT), Gandipet, Hyderabad 500075, Telangana, India

7. Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa 616, Oman

8. Centre of Excellence for Research in Sustainable Chemistry, Department of Chemistry, 20 Federal University of São Carlos, 13565-905 São Carlos, SP, Brazil

9. Environmental Sciences, Department of Chemistry, ITER, Siksha “O” Anusandhan (Deemed to be University), Bhubaneswar 751030, Odisha, India

10. Bioresources and Traditional Knowledge Laboratory, Department of Wildlife and Biodiversity Conservation, Maharaja Sriram Chandra Bhanja Deo University, Sriram Chandra Vihar, Takatpur, Baripada 757003, India

Abstract

The bottom-up synthesis of gold nanoparticles (AuNPs) using Ocimum sanctum essential oil extracts exhibited excellent antimicrobial and therapeutic potential against MCF 7 breast carcinoma through flow cytometry analysis and DNA damage studies.

Publisher

Royal Society of Chemistry (RSC)

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