Synergistically remodulating H<sup>+</sup>/Ca<sup>2+</sup> gradients to induce mitochondrial depolarization for enhanced synergistic cancer therapy-Reference-Cited by-同舟云学术

Synergistically remodulating H⁺/Ca²⁺ gradients to induce mitochondrial depolarization for enhanced synergistic cancer therapy

Published:2023 Issue:41 Volume:14 Page:11532-11545
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Xiaoni¹,Ge Xiyang¹,Guan Xiaowen¹,Ouyang Jin²^ORCID,Na Na¹^ORCID

Affiliation:

1. Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China

2. Department of Chemistry, College of Arts and Sciences, Beijing Normal University at Zhuhai, Zhuhai City, Guangdong Province 519087, China

Abstract

A DNA nanocomplex of Ca@DNA–MF was successfully prepared for synergistic three-channel mitochondrial depolarization via synergistically remodulating H+/Ca2+ gradients, providing a synergistic strategy for enhanced cancer therapy with low toxicity.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC03493C

Reference47 articles.

1. Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

2. Photosynthetic artificial organelles sustain and control ATP-dependent reactions in a protocellular system

3. Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction

4. Warburg and Beyond: The Power of Mitochondrial Metabolism to Collaborate or Replace Fermentative Glycolysis in Cancer

5. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

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