Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning-Reference-Cited by-同舟云学术

Sensing morphogenesis of bone cells under microfluidic shear stress by holographic microscopy and automatic aberration compensation with deep learning

Published:2021 Issue:7 Volume:21 Page:1385-1394
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Xiao Wen¹²³⁴⁵,Xin Lu¹²³⁴⁵,Cao Runyu¹²³⁴⁵,Wu Xintong⁶⁷³⁸⁵,Tian Ran⁶⁷³⁸⁵,Che Leiping¹²³⁴⁵,Sun Lianwen⁶⁷³⁸⁵,Ferraro Pietro⁹¹⁰¹¹¹²^ORCID,Pan Feng¹²³⁴⁵^ORCID

Affiliation:

1. Key Laboratory of Precision Opto-mechatronics Technology

2. School of Instrumentation & Optoelectronic Engineering

3. Beihang University

4. Beijing 100191

5. China

6. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education

7. School of Biological Science and Medical Engineering

8. Beijing

9. CNR

10. Institute of Applied Sciences & Intelligent Systems (ISASI) “E. Caianiello”

11. 80078 Pozzuoli

12. Italy

Abstract

We propose a method to compensate the aberrations of digital holographic microscopy based on a multiple regression convolutional neural network. The experimental verification is carried out by measuring the morphological change of living cells under micro-Fluidic Shear Stress.

Funder

Natural Science Foundation of Beijing Municipality

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D0LC01113D

Reference57 articles.

1. J. Wolff , Das Gesetz der Transform der Knochen , Berlin: Hirschwald , 1892

2. Aging, Osteocytes, and Mechanotransduction