Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution-Reference-Cited by-同舟云学术

Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution

Published:2008 Issue:11 Volume:6 Page:1973
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Anderson Robert F.,Shinde Sujata S.,Maroz Andrej,Boyd Maruta,Palmer Brian D.,Denny William A.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2008/OB/B801859F

Reference27 articles.

1. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

2. Preclinical Testing of the Nitroimidazopyran PA-824 for Activity against Mycobacterium tuberculosis in a Series of In Vitro and In Vivo Models

3. Bactericidal Activity of the Nitroimidazopyran PA-824 in a Murine Model of Tuberculosis

4. Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

5. Prospects for Clinical Introduction of Nitroimidazole Antibiotics for the Treatment of Tuberculosis

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