Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium

Author:

Kopiasz Rafał Jerzy1ORCID,Zabost Anna2ORCID,Myszka Magdalena1,Kuźmińska Aleksandra3,Drężek Karolina1,Mierzejewska Jolanta1ORCID,Tomaszewski Waldemar1,Iwańska Agnieszka2,Augustynowicz-Kopeć Ewa2,Ciach Tomasz3,Jańczewski Dominik1ORCID

Affiliation:

1. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland

2. Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, Warsaw 01-138, Poland

3. Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, Warsaw 00-645, Poland

Abstract

A high significance of the main chain flexibility and an unexpected effect of hydrophobicity on the biological activity in series of ionenes was observed. The most potent among the tested polycations showed high activity toward clinical bacterial isolates.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference67 articles.

1. Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline , World Health Organization , Geneva , 2019 , Licence: CC BY-NC-SA 3.0 IGO

2. Antimicrobial resistance and antibiotic stewardship programs in the ICU: insistence and persistence in the fight against resistance. A position statement from ESICM/ESCMID/WAAAR round table on multi-drug resistance

3. Global Tuberculosis Report 2020 – Reflections on the Global TB burden, treatment and prevention efforts

4. Global tuberculosis report 2020 , World Health Organization , 2020 , Geneva , Licence: CC BY-NC-SA 3.0

5. Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis

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