Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and <i>Mycobacterium</i>-Reference-Cited by-同舟云学术

Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium

Published:2022 Issue:40 Volume:12 Page:26220-26232
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kopiasz Rafał Jerzy¹^ORCID,Zabost Anna²^ORCID,Myszka Magdalena¹,Kuźmińska Aleksandra³,Drężek Karolina¹,Mierzejewska Jolanta¹^ORCID,Tomaszewski Waldemar¹,Iwańska Agnieszka²,Augustynowicz-Kopeć Ewa²,Ciach Tomasz³,Jańczewski Dominik¹^ORCID

Affiliation:

1. Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, Warsaw 00-664, Poland

2. Department of Microbiology, National Tuberculosis and Lung Diseases Research Institute, Płocka 26, Warsaw 01-138, Poland

3. Faculty of Chemical and Process Engineering, Warsaw University of Technology, Waryńskiego 1, Warsaw 00-645, Poland

Abstract

A high significance of the main chain flexibility and an unexpected effect of hydrophobicity on the biological activity in series of ionenes was observed. The most potent among the tested polycations showed high activity toward clinical bacterial isolates.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA04121A

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