Stereoselective coronas regulate the fate of chiral gold nanoparticles in vivo

Author:

Baimanov Didar12ORCID,Wang Liming1ORCID,Liu Ke13,Pan Mengmeng2,Cai Rui1,Yuan Hao1,Huang Wanxia4,Yuan Qingxi4,Zhou Yunlong2ORCID,Chen Chunying156ORCID,Zhao Yuliang156

Affiliation:

1. CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, CAS-HKU Joint Laboratory of Metallomics on Health and Environment, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China

2. Engineering Research Center of Clinical Functional Materials and Diagnosis &Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325000, P. R. China

3. College of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Sichuan province, Chengdu 610059, P. R. China

4. Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China

5. GBA Research Innovation Institute for Nanotechnology, Guangzhou 510700, Guangdong, P. R. China

6. Research Unit of Nanoscience and Technology, Chinese Academy of Medical Sciences, Beijing 100730, P. R. China

Abstract

Formation of chirality-specific protein corona on gold nanoparticles promotes recognition by lipoproteins, complements, and acute phase proteins that mediates LDL receptor-involved cell uptake and tissue accumulation in vivo.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Beijing Municipal Health Commission

Science and Technology Plan Project of Wenzhou, China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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