Chelation of [111In]In3+ with the dual-size-selective macrocycles py-macrodipa and py2-macrodipa

Author:

Lee Kevin K.1ORCID,Chakraborty Mou23,Hu Aohan1,Kanagasundaram Thines1,Thorek Daniel L. J.234,Wilson Justin J.1ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, 14853, USA

2. Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

3. Program in Quantitative Molecular Therapeutics, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

4. Department of Biomedical Engineering, Washington University, St. Louis, Missouri, 63110, USA

Abstract

The dual-size-selective chelators py-macrodipa and py2-macrodipa were investigated for their abilities to complex [111In]In3+. These chelators form highly stable complexes of this diagnostic radiometal under mild radiolabeling conditions.

Funder

Division of Chemistry

Deutscher Akademischer Austauschdienst

National Institute of Biomedical Imaging and Bioengineering

National Cancer Institute

Publisher

Royal Society of Chemistry (RSC)

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