One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole-Reference-Cited by-同舟云学术

One-pot metal-free synthesis of highly substituted pyrroles from 2-acetyl-3-methylene-1,4-dicarbonyl compounds and primary amines via TBHP and activated carbon oxidative aromatization of dihydropyrrole

Published:2014 Issue:29 Volume:4 Page:15007-15010
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Yang Wei¹²³⁴,Zhou Yu¹²³⁴,Sun Haifeng¹²³⁴,Zhang Lei¹²³⁴,Zhao Fei¹²³⁴,Liu Hong¹²³⁴

Affiliation:

1. CAS Key Laboratory of Receptor Research

2. Shanghai Institute of Materia Medica

3. Chinese Academy of Sciences

4. Shanghai 201203, P. R. China

Abstract

A metal-free cascade process for the synthesis of highly substituted pyrroles with high yields and broad substrate tolerance via enamine, aza-Michael addition and TBHP, activated carbon oxidative aromatization is reported.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C3RA47782G

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1. Mechanism of action in a 4,5-diarylpyrrole series of selective cyclo-oxygenase-2 inhibitors

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