Design, synthesis and anticancer activity of furochromone and benzofuran derivatives targeting VEGFR-2 tyrosine kinase-Reference-Cited by-同舟云学术

Design, synthesis and anticancer activity of furochromone and benzofuran derivatives targeting VEGFR-2 tyrosine kinase

Published:2015 Issue:32 Volume:5 Page:25312-25324
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Abdelhafez Omaima M.¹²³,Ali Hamed I.⁴⁵⁶⁷⁸,Amin Kamelia M.⁸⁹¹⁰³,Abdalla Mohamed M.¹¹¹²³,Ahmed Eman Y.¹²³

Affiliation:

1. Chemistry of Natural Products Dept

2. National Research Center

3. Egypt

4. Pharmaceutical Sciences Dept

5. Irma Lerma Rangel College of Pharmacy

6. Texas A&M Health Science Center

7. USA

8. Pharmaceutical Chemistry Dept

9. Faculty of Pharmacy

10. Cairo University

11. Research Unit

12. Mapco Pharmaceutical industries Balteim

Abstract

Furochromone and benzofuran derivatives were synthesized, docked and evaluated for their anti-VEGFR-2 activity, cytotoxicity, and in vivo antiprostate cancer activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA16228E

Reference39 articles.

1. Angiogenesis in cancer and other diseases

2. Angiogenesis-dependent diseases

3. The biology of VEGF and its receptors

4. The role of protein phosphorylation in human health and disease.

5. Receptor tyrosine kinases as targets for anticancer drugs

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