Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist-Reference-Cited by-同舟云学术

Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist

Published:2017 Issue:1 Volume:8 Page:611-615
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Barber David M.¹²³⁴,Liu Shu-An¹²³⁴,Gottschling Kevin⁵⁶⁷⁴,Sumser Martin¹²³⁴,Hollmann Michael⁵⁶⁷⁴,Trauner Dirk¹²³⁴

Affiliation:

1. Department of Chemistry and Center for Integrated Protein Science

2. Ludwig Maximilians University Munich

3. 81377 Munich

4. Germany

5. Department of Biochemistry I – Receptor Biochemistry

6. Ruhr-Universität-Bochum

7. Bochum 44780

Abstract

We have developed the first photoswitchable AMPA receptor antagonist, termedShuBQX-3. It permits the precise optical control of AMPA receptors and exhibits a remarkable red-shifting of its photoswitching properties when bound to the receptor.

Funder

European Commission

Ruhr-Universität Bochum

European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/SC/C6SC01621A

Reference39 articles.

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