ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates-Reference-Cited by-同舟云学术

ItaCORMs: conjugation with a CO-releasing unit greatly enhances the anti-inflammatory activity of itaconates

Published:2021 Issue:12 Volume:12 Page:2053-2059
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Krause Bernhard M.¹^ORCID,Bauer Britta²,Neudörfl Jörg-Martin¹,Wieder Thomas²³,Schmalz Hans-Günther¹^ORCID

Affiliation:

1. University of Cologne, Department of Chemistry, Greinstr. 4, 5939 Köln, Germany

2. University Medical Center Tübingen, Department of Dermatology, Liebermeisterstr. 25, 72076 Tübingen, Germany

3. Physiologisches Institut, Abteilung für Vegetative und Klinische Physiologie, Eberhard-Karls-Universität Tübingen, Wilhelmstr. 56, 72074 Tübingen, Germany

Abstract

New powerful anti-inflammatory agents (prodrugs) were developed which act by esterase-triggered, simultaneous release of itaconate and the gasotransmitter carbon monoxide.

Funder

Deutsche Forschungsgemeinschaft

Wilhelm Sander-Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00163A

Reference48 articles.

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