Potent cyclometallated Pd(ii) antitumor complexes bearing α-amino acids: synthesis, structural characterization, DNA/BSA binding, cytotoxicity and molecular dynamics simulation

Author:

Abedanzadeh Sedigheh12345ORCID,Karami Kazem1234ORCID,Rahimi Mostafa1234,Edalati Masoud1234,Abedanzadeh Mozhgan6784,Tamaddon Ali mohammad6784,Jahromi Maryam Dehdashti1234,Amirghofran Zahra910784,Lipkowski Janusz111213,Lyczko Krzysztof141513

Affiliation:

1. Department of Chemistry

2. Isfahan University of Technology

3. Isfahan

4. Iran

5. Institute of Biochemistry and Biophysics (IBB)

6. Center for Nanotechnology in Drug Delivery

7. Shiraz University of Medical Sciences

8. Shiraz

9. Department of Immunology

10. School of Medicine

11. Cardinal Stefan Wyszynski University in Warsaw

12. Warsaw

13. Poland

14. Institute of Nuclear Chemistry and Technology

15. 03-19 Warszawa

Abstract

Synthesis, characterization, spectroscopic, biological, and molecular modeling studies on the DNA/BSA binding interactions of new cyclometallated Pd(ii) complexes bearing α-amino acids were investigated.

Funder

Iran National Science Foundation

Isfahan University of Technology

Shiraz University of Medical Sciences

Kharazmi University

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

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