Enantioselective synthesis of tricyclic oxoquinolines <i>via</i> NHC-catalyzed Michael-aldol-lactamization-dehydration cascade-Reference-Cited by-同舟云学术

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Enantioselective synthesis of tricyclic oxoquinolines via NHC-catalyzed Michael-aldol-lactamization-dehydration cascade

Published:2024 Issue:32 Volume:60 Page:4290-4293
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Barik Shilpa¹,Sankar Ganga¹,Biju Akkattu T.¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Indian Institute of Science, Bangalore-560012, India

Abstract

NHC-catalyzed cascade reaction of enals with malonates bearing a 2-aminophenyl group leading to the enantioselective synthesis of tricyclic oxoquinolines via the chiral α,β-unsaturated acylazoliums is presented.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CC/D4CC00502C

Reference47 articles.

1. 4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction

2. Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

3. Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities

4. Enantioselective Total Synthesis of theMelodinusAlkaloid (+)-Meloscine

5. Total Synthesis of Meloscine by a [2+2]-Photocycloaddition/Ring-Expansion Route

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