Synthesis and biological evaluation of novel technetium-99m-labeled phenylquinoxaline derivatives as single photon emission computed tomography imaging probes targeting β-amyloid plaques in Alzheimer's disease-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel technetium-99m-labeled phenylquinoxaline derivatives as single photon emission computed tomography imaging probes targeting β-amyloid plaques in Alzheimer's disease

Published:2017 Issue:33 Volume:7 Page:20582-20590
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Iikuni Shimpei¹²³⁴⁵,Ono Masahiro¹²³⁴⁵^ORCID,Tanimura Keiichi¹²³⁴⁵,Watanabe Hiroyuki¹²³⁴⁵,Yoshimura Masashi¹²³⁴⁵,Saji Hideo¹²³⁴⁵

Affiliation:

1. Department of Patho-Functional Bioanalysis

2. Graduate School of Pharmaceutical Sciences

3. Kyoto University

4. Kyoto 606-8501

5. Japan

Abstract

The development of an imaging probe targeting β-amyloid (Aβ) plaques in Alzheimer's disease labeled with technetium-99m, the most commonly used radioisotope for clinical diagnoses, has been strongly anticipated.

Funder

Japan Society for the Promotion of Science

Japan Research Foundation for Clinical Pharmacology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA28395K

Reference36 articles.

1. PET imaging of amyloid in Alzheimer's disease

2. Alzheimer's Disease and Parkinson's Disease