Environmental manipulation to promote stem cell survival in vivo: use of aggregation, oxygen carrier, and BMP-2 co-delivery strategies

Author:

Allen Ashley B.12345,Zimmermann Josh A.12345,Burnsed Olivia A.12345,Yakubovich Doron Cohn6789,Stevens Hazel Y.102345,Gazit Zulma678911,McDevitt Todd C.12345,Guldberg Robert E.102345

Affiliation:

1. Wallace H. Coulter Department of Biomedical Engineering

2. Parker H. Petit Institute for Bioengineering & Bioscience

3. Georgia Institute of Technology

4. Atlanta

5. USA

6. Skeletal Biotech Laboratory

7. The Hebrew University-Hadassah Faculty of Dental Medicine

8. Jerusalem

9. Israel

10. George W. Woodruff School of Mechanical Engineering

11. Regenerative Medicine Institute

Abstract

While mesenchymal stem cell (MSC)-based strategies for critically-sized bone defect repair hold promise, poor cell survival in vivo remains a significant barrier to the translation of these therapeutics.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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