Pilot-scale co-precipitation synthesis of a novel active ingredient made of ultrasmall iron (oxyhydr)oxide nanoparticles for the treatment of hyperphosphatemia-Reference-Cited by-同舟云学术

Pilot-scale co-precipitation synthesis of a novel active ingredient made of ultrasmall iron (oxyhydr)oxide nanoparticles for the treatment of hyperphosphatemia

Published:2024 Issue:23 Volume:14 Page:16117-16127
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Spicher Magdalena Teresa¹²^ORCID,Schwaminger Sebastian Patrick²³⁴^ORCID,von der Haar-Leistl Daniela¹,Peralta Marian Montiel¹,Mikacevic Georgina¹,Wagner Friedrich Ernst⁵,Berensmeier Sonja²

Affiliation:

1. Fraunhofer Institute for Process Engineering and Packaging (IVV), Giggenhauser Str. 35, 85354 Freising, Germany

2. Chair of Bioseparation Engineering, School of Engineering and Design, Technical University of Munich, Boltzmannstraße 15, 85748, Garching, Germany

3. Division of Medicinal Chemistry, Otto Loewi Research Center, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria

4. BioTechMed-Graz, Austria

5. Department of Physics, Technical University of Munich, James-Franck-Straße 1, 85748 Garching, Germany

Abstract

Ultrasmall iron (oxyhydr)oxide nanoparticles can be prepared with a yield >40 g L−1 on a pilot scale by co-precipitation without losing their exceptionally high phosphate-binding efficacy. Only slight changes in composition were observed, attributed to a reduction in core size.

Funder

Bundesministerium für Bildung und Forschung

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA02719A

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