Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver-Reference-Cited by-同舟云学术

Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver

Published:2021 Issue:4 Volume:9 Page:1449-1463
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zhang Rui¹²³⁴,El-Mayta Rakan¹²³⁴,Murdoch Timothy J.⁵²³⁴^ORCID,Warzecha Claude C.⁶⁷²³⁴,Billingsley Margaret M.¹²³⁴,Shepherd Sarah J.¹²³⁴,Gong Ningqiang¹²³⁴,Wang Lili⁶⁷²³⁴,Wilson James M.⁶⁷²³⁴,Lee Daeyeon⁵²³⁴^ORCID,Mitchell Michael J.¹²³⁴⁸^ORCID

Affiliation:

1. Department of Bioengineering

2. University of Pennsylvania

3. Philadelphia

4. USA

5. Department of Chemical and Biomolecular Engineering

6. Gene Therapy Program

7. Perelman School of Medicine

8. Abramson Cancer Center

Abstract

High-throughput in vivo screening identified several LNPs formulated with DOPE that preferentially accumulated in the liver, while identical LNPs formulated with DSPC preferentially accumulated in the spleen.

Funder

National Science Foundation

Burroughs Wellcome Fund

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/BM/D0BM01609H

Reference58 articles.

1. Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs