Aza-BODIPY nanomicelles as versatile agents for the in vitro and in vivo singlet oxygen-triggered apoptosis of human breast cancer cells

Author:

Adarsh Nagappanpillai123,Babu P. S. Saneesh45367,Avirah Rekha R.123,Viji Mambattakkara123,Nair S. Asha453,Ramaiah Danaboyina893ORCID

Affiliation:

1. Chemical Sciences and Technology Division CSIR-National Institute for Interdisciplinary Science and Technology (CSIR-NIIST)

2. Thiruvananthapuram – 695 019

3. India

4. Rajiv Gandhi Centre for Biotechnology

5. Thiruvananthapuram – 695014

6. MVR Cancer centre and Research Institute

7. Kozhikode – 673601

8. CSIR-North East Institute of Science and Technology (CSIR-NEIST)

9. Jorhat – 785 006

Abstract

Singlet oxygen mediated apoptosis in MDA MB 231 cells and inhibition of growth of tumor xenografts in NOD/SCID mice achieved through aza-BODIPY nanomicelles plus NIR light thereby demonstrating their promising use for solid tumors.

Funder

Department of Biotechnology, Ministry of Science and Technology

Council of Scientific and Industrial Research, India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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