An intelligent NIR-responsive chelate copper-based anticancer nanoplatform for synergistic tumor targeted chemo-phototherapy-Reference-Cited by-同舟云学术

An intelligent NIR-responsive chelate copper-based anticancer nanoplatform for synergistic tumor targeted chemo-phototherapy

Published:2017 Issue:40 Volume:9 Page:15685-15695
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Feng Qianhua¹²³⁴⁵,Zhang Wanxia¹²³⁴,Li Yuzhen¹²³⁴,Yang Xuemei¹²³⁴,Hao Yongwei¹²³⁴⁵,Zhang Hongling¹²³⁴⁵,Li Wei⁶⁷⁸⁴,Hou Lin¹²³⁴⁵,Zhang Zhenzhong¹²³⁴⁵^ORCID

Affiliation:

1. School of Pharmaceutical Sciences

2. Zhengzhou University

3. Zhengzhou 450001

4. China

5. Collaborative Innovation Center of New Drug Research and Safety Evaluation

6. School of Pharmacy

7. China Medical University

8. Shenyang 110001

Abstract

The chelate copper-based anticancer drug bleomycin (BLM) is usually believed to bind metal ions especially Cu(ii) to generate the “activated BLM” for DNA cleavage. This study offered a platform for simultaneous NIR-mediated temperature-responsive BLM and copper ion release, which further initiated the generation of the “activated BLM”.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NR/C7NR05003H

Reference36 articles.

1. Bleomycins: towards better therapeutics

2. Copper-dependent cleavage of DNA by bleomycin

3. Cytotoxic and antitumor properties of bleomycin and several of its metal complexes

4. Nanoparticle-Mediated Delivery of Bleomycin

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