Suppressed hydration in metoclopramide hydrochloride by salt cocrystallisation
Author:
Affiliation:
1. Department of Chemistry and Materials Science
2. Graduate School of Science and Engineering
3. Tokyo Institute of Technology
4. Tokyo 152-8551
5. Japan
6. Department of Chemistry
7. School of Science
Abstract
Salt cocrystallisation method successfully suppressed hydration and lowered the dissolution rate of the pharmaceutical salt crystals.
Funder
Ministry of Education, Culture, Sports, Science and Technology
Publisher
Royal Society of Chemistry (RSC)
Subject
Condensed Matter Physics,General Materials Science,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CE/C8CE00129D
Reference70 articles.
1. H. G. Brittain , Polymorphism in Pharmaceutical Solids , Informa Healthcare , New York , 2nd edn, 2009
2. Trends in Solubility of Polymorphs
3. Factors affecting crystallization of hydrates
4. Polymorph Impact on the Bioavailability and Stability of Poorly Soluble Drugs
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