Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing-Reference-Cited by-同舟云学术

Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

Published:2020 Issue:8 Volume:20 Page:1461-1471
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Rothbauer Mario¹²³⁴⁵^ORCID,Höll Gregor¹²³⁴,Eilenberger Christoph¹²³⁴,Kratz Sebastian R. A.¹²³⁴,Farooq Bilal¹²³⁴,Schuller Patrick¹²³⁴,Olmos Calvo Isabel⁶⁷⁸⁹⁴,Byrne Ruth A.⁵¹⁰¹¹⁹⁴,Meyer Brigitte⁵¹⁰¹¹⁹⁴,Niederreiter Birgit⁵¹⁰¹¹⁹⁴,Küpcü Seta¹²¹³¹⁴¹⁵⁴,Sevelda Florian⁵¹¹⁹⁴,Holinka Johannes⁵¹¹⁹⁴,Hayden Oliver¹⁶¹⁷¹⁸¹⁹²⁰,Tedde Sandro F.²¹²²²³²⁴²⁵,Kiener Hans P.⁶⁷⁸⁹⁴,Ertl Peter¹²³⁴^ORCID

Affiliation:

1. Faculty of Technical Chemistry

2. Vienna University of Technology

3. 1060 Vienna

4. Austria

5. Department of Orthopedics and Trauma Surgery

6. Division of Rheumatology

7. Department of Medicine III

8. Medical University Vienna

9. 1090 Vienna

10. Karl Chiari Lab for Orthopaedic Biology

11. Medical University of Vienna

12. Institute of Synthetic Bioarchitectures

13. Department of Nanobiotechnology

14. University of Natural Resources and Life Sciences

15. 1190 Vienna

16. Heinz-Nixdorf-Chair of Biomedical Electronics

17. Department of Electrical and Computer Engineering

18. TranslaTUM

19. Campus Klinikum rechts der Isar

20. Technical University of Munich

21. Siemens Healthcare GmbH

22. Technology Center

23. TI TC BMT

24. 91058 Erlangen

25. Germany

Abstract

We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.

Funder

Vienna Science and Technology Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2020/LC/C9LC01097A

Reference53 articles.

1. Evolving concepts of rheumatoid arthritis

2. Microfluidic processing of synovial fluid for cytological analysis

3. Integration of fiber optic-particle plasmon resonance biosensor with microfluidic chip