A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells-Reference-Cited by-同舟云学术

A fluorescent light-up probe with AIE characteristics for specific mitochondrial imaging to identify differentiating brown adipose cells

Published:2014 Issue:61 Volume:50 Page:8312-8315
ISSN:1359-7345
Container-title:Chem. Commun.
language:en
Short-container-title:Chem. Commun.

Author:

Gao Meng¹²,Sim Choon Kiat³⁴⁵,Leung Chris Wai Tung⁶⁷⁸⁹¹⁰,Hu Qinglian¹¹¹²¹³,Feng Guangxue¹¹¹²¹³,Xu Feng³⁴⁵¹⁴¹⁵,Tang Ben Zhong⁶⁷⁸⁹¹⁰,Liu Bin¹²¹¹¹²¹³

Affiliation:

1. Institute of Materials Research and Engineering (A*STAR)

2. , Singapore 117602

3. Singapore Institute for Clinical Sciences

4. Brenner Centre for Molecular Medicine (A*STAR)

5. , Singapore 117609

6. Department of Chemistry

7. Division of Biomedical Engineering

8. The Hong Kong University of Science and Technology

9. Clear Water Bay

10. Kowloon, China

11. Department of Chemical and Biomolecular Engineering

12. National University of Singapore

13. Singapore 117576

14. Department of Biochemistry

15. Yong Loo Lin School of Medicine

Abstract

We report the design and synthesis of a specific mitochondrial fluorescent probe AIE-MitoGreen-1 with AIE characteristics to monitor the mitochondrial morphology changes and identify the differentiation process of living brown adipose cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2014/CC/C4CC00452C

Reference19 articles.

1. Brown Adipose Tissue in Adult Humans: A Metabolic Renaissance

2. Adipose tissue browning and metabolic health

3. Anatomical and Functional Assessment of Brown Adipose Tissue by Magnetic Resonance Imaging

4. Selective mitochondrial staining with small fluorescent probes: importance, design, synthesis, challenges and trends for new markers

5. Evidence for two types of brown adipose tissue in humans

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