Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore-Reference-Cited by-同舟云学术

Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore

Published:2023 Issue:30 Volume:52 Page:10338-10347
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Fink Krzysztof¹²^ORCID,Cebula Jakub¹²,Tošner Zdeněk³,Psurski Mateusz⁴,Uchman Mariusz²^ORCID,Goszczyński Tomasz M.¹

Affiliation:

1. Laboratory of Biomedical Chemistry, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolf Weigl St., 53-114 Wrocław, Poland

2. Department of Physical and Macromolecular Chemistry, Faculty of Science, Charles University, Hlavova 2030, 128 40 Prague 2, Czechia

3. NMR Laboratory, Faculty of Science, Charles University, Hlavova 2030, 128 40 Prague 2, Czechia

4. Laboratory of Experimental Anticancer Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 12 Rudolf Weigl St., 53-114 Wrocław, Poland

Abstract

Cobalt bis(dicarbollide) (COSAN) is a DNA-neutral pharmacophore without significant interactions with DNA. As a result, DNA is not necessary for COSAN to induce cytotoxicity, which is most likely protein- or cell membrane-dependent.

Funder

Narodowe Centrum Nauki

Narodowa Agencja Wymiany Akademickiej

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/DT/D3DT01836A

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