Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III-Reference-Cited by-同舟云学术

Unravelling the inhibitory zinc ion binding site and the metal exchange mechanism in human DPP III

Published:2021 Issue:23 Volume:23 Page:13267-13275
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Tomić Antonija¹²³,Brkić Hrvoje⁴⁵³⁴⁶^ORCID,Matić Antonia¹²³,Tomić Sanja¹²³^ORCID

Affiliation:

1. Ruđer Bošković Institute

2. Division of Organic Chemistry and Biochemistry

3. Croatia

4. J. J. Strossmayer University of Osijek

5. Faculty of Medicine

6. Faculty of Dental Medicine and Health

Abstract

The binding of two Zn ions to human DPP III was investigated. Simulations showed translocation of Zn ion from the inhibitory to the catalytic binding site, accompanied by displacement of the catalytic Zn from the interdomain cleft.

Funder

Hrvatska Zaklada za Znanost

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CP/D1CP01302E

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3. Dipeptidyl peptidase 3 modulates the renin–angiotensin system in mice

4. Concerted nitrogen inversion and hydrogen bonding to Glu451 are responsible for protein-controlled suppression of the reverse reaction in human DPP III

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