Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD<sub>3</sub>-containing scaffolds-Reference-Cited by-同舟云学术

Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD₃-containing scaffolds

Published:2022 Issue:18 Volume:58 Page:3015-3018
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Xiao Xiao¹^ORCID,Huang Yin-Qiu¹,Tian Hong-Yu¹,Bai Jun¹,Cheng Fei¹,Wang Xu¹,Ke Miao-Lin¹^ORCID,Chen Fen-Er¹²³^ORCID

Affiliation:

1. Institute of Pharmaceutical Science and Technology, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, People's Republic of China

2. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry Fudan University, 220 Handan Road, Shanghai 200433, People's Republic of China

3. Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, People's Republic of China

Abstract

We report a method for the synthesis of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This reacts with various nucleophiles to give SCD3 analogues with high deuterium levels (>99% D).

Funder

Natural Science Foundation of Zhejiang Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC07184J

Reference64 articles.

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