Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors-Reference-Cited by-同舟云学术

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Design, synthesis and biological activity evaluation of novel conjugated sialic acid and pentacyclic triterpene derivatives as anti-influenza entry inhibitors

Published:2016 Issue:10 Volume:7 Page:1932-1945
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Han Xu¹²³⁴⁵,Shi Yongying¹²³⁴⁵,Si Longlong¹²³⁴⁵,Fan Zibo¹²³⁴⁵,Wang Han¹²³⁴⁵,Xu Renyang¹²³⁴⁵,Jiao Pingxuan¹²³⁴⁵,Meng Kun¹²³⁴⁵,Tian Zhenyu¹²³⁴⁵,Zhou Xiaoshu¹²³⁴⁵,Jin Hongwei¹²³⁴⁵,Wu Xinyu⁶⁷⁸⁹³,Chen Hong⁶⁷⁸⁹³,Zhang Yongmin¹⁰¹¹¹²¹³¹⁴,Zhang Lihe¹²³⁴⁵,Xiao Sulong¹²³⁴⁵,Zhou Demin¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. School of Pharmaceutical Sciences

3. Peking University

4. Beijing 100191

5. China

6. Institute of Systems Biomedicine

7. Department of Pathology

8. School of Basic Medical Sciences

9. Beijing Key Laboratory of Tumor Systems Biology

10. Institut Parisien de Chimie Moléculaire

11. CNRS UMR 8232

12. Université Pierre & Marie Curie-Paris 6

13. 75005 Paris

14. France

Abstract

A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/MD/C6MD00292G

Reference46 articles.

1. Antiviral strategies against influenza virus: towards new therapeutic approaches

2. Avian Influenza Virus (H5N1): a Threat to Human Health

3. Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus

4. Avian and pandemic influenza: An overview

5. Global circulation patterns of seasonal influenza viruses vary with antigenic drift

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