Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA-Reference-Cited by-同舟云学术

Reversible and formaldehyde-mediated covalent binding of a bis-amino mitoxantrone analogue to DNA

Published:2016 Issue:20 Volume:14 Page:4728-4738
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Konda Shyam K.¹²³⁴⁵,Kelso Celine⁶⁷⁸⁹,Pumuye Paul P.¹⁰¹¹¹²⁹,Medan Jelena¹⁰¹¹¹²⁹¹³,Sleebs Brad E.¹³¹⁴¹⁵⁹¹⁶^ORCID,Cutts Suzanne M.¹⁰¹¹¹²⁹,Phillips Don R.¹⁰¹¹¹²⁹,Collins J. Grant¹²³⁴⁵

Affiliation:

1. School of Physical

2. Environmental and Mathematical Sciences

3. University of New South Wales

4. Australian Defence Force Academy

5. Campbell

6. School of Chemistry

7. University of Wollongong

8. Wollongong

9. Australia

10. Biochemistry Department

11. La Trobe University

12. Bundoora

13. Chemical Biology Division and Infection and Immunity Division

14. The Walter and Eliza Hall Institute of Medical Research

15. Parkville

16. Department of Medical Biology

Abstract

The ability of the anthracenedione anticancer drug WEHI-150 to form covalent adducts with DNA, after activation by formaldehyde, has been studied by mass spectrometry, HPLC and NMR spectroscopy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB00561F

Reference38 articles.

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2. Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

3. Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase IIβ Poisons and Cytotoxic Agents

4. Anthrazykline in der Krebstherapie

5. Mitoxantrone (novantrone): a review of experimental and early clinical studies

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