Manipulating the regioselectivity of a Solanum lycopersicum epoxide hydrolase for the enantioconvergent synthesis of enantiopure alkane- and alkene-1,2-diols-Reference-Cited by-同舟云学术

Manipulating the regioselectivity of a Solanum lycopersicum epoxide hydrolase for the enantioconvergent synthesis of enantiopure alkane- and alkene-1,2-diols

Published:2020 Issue:17 Volume:10 Page:5886-5895
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Hu Bochun¹²³⁴⁵^ORCID,Hu Die⁶⁴⁵⁷,Zhang Dong¹²³⁴⁵,Wen Zheng¹²³⁴⁵,Zang Jia⁸⁹⁷,Wu Minchen⁶⁴⁵⁷^ORCID

Affiliation:

1. Key Laboratory of Carbohydrate Chemistry and Biotechnology

2. Ministry of Education

3. School of Biotechnology

4. Jiangnan University

5. Wuxi 214122

6. Wuxi School of Medicine

7. China

8. The Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University

9. Wuxi 214002

Abstract

This work engineered a superior double-site mutant SlEH1^W106T/F189L used for the enantioconvergent biosynthesis of (R)-1b–6b with high ee_p values.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CY/D0CY00990C

Reference44 articles.

1. Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates

2. Total Synthesis of Mniopetals A, B, C and D

3. Stereoselective synthesis of umuravumbolide

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5. Highly Enantioselective Iron-Catalyzed cis -Dihydroxylation of Alkenes with Hydrogen Peroxide Oxidant via an FeIII -OOH Reactive Intermediate

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