Convenient multicomponent synthesis of furo[3,2-c]coumarins in the promoting medium DIPEAc and assessment of their therapeutic potential through in silico pharmacophore based target screening

Author:

Shaikh Shabnam M.1,Yadav Vinay K.2,Mali Ghanshyam3,Bondle Giribala M.1,Kumar Akhilesh4ORCID,Erande Rohan D.3,Bhattacharyya Sudipta2ORCID,Bhosle Manisha R.1ORCID

Affiliation:

1. Department of Chemistry, Dr Babasaheb Ambedkar Marathwada University, Aurangabad 431004, MS, India

2. Department of Bioscience & Bioengineering, Indian Institute of Technology Jodhpur, Jodhpur 342037, Rajasthan, India

3. Department of Chemistry, Indian Institute of Technology Jodhpur, Jodhpur 342037, Rajasthan, India

4. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India

Abstract

A one-pot three-component approach for the synthesis of dihydrofuro[3,2-c]coumarins was developed via the reaction of aryl/hetryl aldehydes, substituted phenacyl bromides and 4-hydroxycoumarin using N,N-diisopropyl ethyl ammonium acetate as the promoting medium.

Funder

Indian Institute of Technology Jodhpur

Indian Institute of Technology Kanpur

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

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