Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-<i>d</i>]pyrimidin-4-one as a phosphodiesterase 10A inhibitor-Reference-Cited by-同舟云学术

Structure-based discovery and bio-evaluation of a cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-one as a phosphodiesterase 10A inhibitor

Published:2022 Issue:3 Volume:12 Page:1576-1591
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Al-Nema Mayasah¹,Gaurav Anand¹^ORCID,Lee Vannajan Sanghiran²,Gunasekaran Baskaran³,Lee Ming Tatt¹⁴⁵,Okechukwu Patrick³,Nimmanpipug Piyarat⁶⁷^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, UCSI University, Kuala Lumpur 56000, Malaysia

2. Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, 50603, Malaysia

3. Faculty of Applied Sciences, UCSI University, Kuala Lumpur 56000, Malaysia

4. Office of Postgraduate Studies, UCSI University, Kuala Lumpur 56000, Malaysia

5. Graduate Institute of Pharmacology, College of Medicine, National Taiwan University, 10051 Taipei, Taiwan

6. Department of Chemistry, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

7. Center of Excellence for Innovation in Analytical Science and Technology for Biodiversity-based Economic and Society (I-ANALY-S-T_B.BES-CMU), Chiang Mai University, 50200, Thailand

Abstract

Phosphodiesterase10A (PDE10A) is a potential therapeutic target for the treatment of several neurodegenerative disorders.

Funder

Chiang Mai University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D1RA07649C

Reference42 articles.

1. Role of phosphodiesterases in neurological and psychiatric disease

2. The Neurobiology of Slow Synaptic Transmission

3. Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

4. Advances in targeting cyclic nucleotide phosphodiesterases

5. Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase

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