Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice-Reference-Cited by-同舟云学术

Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice

Published:2015 Issue:10 Volume:5 Page:7285-7290
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Yang Yong¹²³⁴⁵,Bai Ting¹²³⁴⁵,Sun Peng⁶⁷⁸,Lian Li-Hua¹²³⁴⁵,Yao You-Li¹²³⁴⁵,Zheng Hui-Xing¹²³⁴⁵,Li Xin¹²³⁴⁵,Li Jin-Bin¹²³⁴⁵,Wu Yan-Ling¹²³⁴⁵,Nan Ji-Xing¹²³⁴⁵

Affiliation:

1. Key Laboratory for Natural Resource of Changbai Mountain & Functional Molecules

2. Ministry of Education

3. College of Pharmacy

4. Yanbian University

5. Yanji 133002

6. Yanbian University Hospital

7. Yanji 133000

8. China

Abstract

This study is the first report on hepatoprotective effect of thymoquinone induced byd-GalN/LPS. Thymoquinone alleviated the progress ofd-GalN/LPS induced acute hepatic failure via attenuating hepatocytes apoptosis and MAPK signaling pathway.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C4RA15065A

Reference31 articles.

1. Hepatoprotective effects of erythropoietin on D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice

2. Baicalein inhibits nuclear factor-κB and apoptosis via c-FLIP and MAPK in d-GalN/LPS induced acute liver failure in murine models

3. Aqueous Extract of Gracilaria tenuistipitata Suppresses LPS-Induced NF-κB and MAPK Activation in RAW 264.7 and Rat Peritoneal Macrophages and Exerts Hepatoprotective Effects on Carbon Tetrachloride-Treated Rat

4. Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice

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