The molecular steps of citrinin biosynthesis in fungi
Author:
Affiliation:
1. College of Food Science and Technology
2. Huazhong Agricultural University
3. Wuhan 430070
4. P. R. China
5. Institut für Organische Chemie
6. Leibniz Universität Hannover
7. 30167 Hannover
8. Germany
9. School of Chemistry
Abstract
Heterologous expression of the citrinin polyketide synthase, CitS, plus the tailoring enzymes CitA–CitE fromMonascus ruberhas fully elucidated the biosynthetic pathway to citrinin for the first time, showing relationships to tropolone, azaphilone and sorbicillinoid biosynthetic pathways in fungi.
Funder
China Scholarship Council
Deutsche Forschungsgemeinschaft
Gottfried Wilhelm Leibniz Universität Hannover
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC04027B
Reference40 articles.
1. Studies in the Biochemistry of Micro-organisms. Part XIV.—On the production and chemical constitution of a new yellow colouring mater, citrinin, produced from glucose by Penicillium
2. Genome, Transcriptome, and Functional Analyses of Penicillium expansum Provide New Insights Into Secondary Metabolism and Pathogenicity
3. Production of citrinin by various species ofMonascus
4. Mechanism of citrinin-induced dysfunction of mitochondria. I. Effects on respiration, enzyme activities and membrane potential of renal cortical mitochondria
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