Phosphorous pentoxide-free bioactive glass exhibits dose-dependent angiogenic and osteogenic capacities which are retained in glass polymeric composite scaffolds

Author:

Font Tellado Sonia1,Delgado José Angel23,Poh Su Ping Patrina14,Zhang Wen56,García-Vallés Maite7,Martínez Salvador7,Gorustovich Alejandro8,Morejón Lizette2,van Griensven Martijn19ORCID,Balmayor Elizabeth Rosado110ORCID

Affiliation:

1. Experimental Trauma Surgery, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany

2. Center for Biomaterials, University of Havana, 10400 Havana, Cuba

3. Universitat Internacional de Catalunya, 08195 Barcelona, Spain

4. Berlin Institute of Health at Charité – Universitätsmedizin Berlin, Julius Wolff Institute, 13353 Berlin, Germany

5. Institute of Molecular Immunology and Experimental Oncology, Klinikum rechts der Isar, Technical University of Munich, 81675 Munich, Germany

6. Ethris GmbH, 82152 Planegg, Germany

7. Mineralogy, Petrology and Applied Geology Department, University of Barcelona, 08028 Barcelona, Spain

8. Interdisciplinary Materials Group-IESIING-UCASAL, INTECIN UBA-CONICET, A4400EDD Salta, Argentina

9. cBITE, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6200 MD Maastricht, the Netherlands

10. IBE, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, 6200 MD Maastricht, the Netherlands

Abstract

New P2O5-free, silicate-based bioactive glass showing angiogenic and osteogenic properties. Glass polymeric composite scaffolds showed improved mechanics and biocompatibility while stimulating cell differentiation.

Funder

Consejo Nacional de Investigaciones Científicas y Técnicas

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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