Photoactivated biscarbocyanine dye with two conjugated chromophores: complexes with albumin, photochemical and phototoxic properties

Author:

Radchenko Alexandra S.123ORCID,Kostyukov Alexey A.123ORCID,Markova Alina A.423ORCID,Shtil Alexander A.523ORCID,Nekipelova Tatiana D.123ORCID,Borissevitch Iouri E.67897ORCID,Kuzmin Vladimir A.123ORCID

Affiliation:

1. Emanuel Institute of Biochemical Physics RAS

2. Moscow

3. Russia

4. A.N. Nesmeyanov Institute of Organoelement Compounds RAS

5. Blokhin National Medical Research Center of Oncology

6. Universidade de São Paulo

7. Brazil

8. Instituto de Física

9. Universidade Federal de Goiás

Abstract

Biscarbocyanine dye forms two types of complexes with human serum albumin and has a high photocytotoxicity towards tumor cells.

Funder

Russian Science Foundation

Publisher

Springer Science and Business Media LLC

Subject

Physical and Theoretical Chemistry

Reference43 articles.

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2. Photosensitizer (PS)-cyanine dye (CD) conjugates: Impact of the linkers joining the PS and CD moieties and their orientation in tumor-uptake and photodynamic therapy (PDT)

3. M. Miwa , Photodynamic Characteristics of ICG Fluorescence Imaging , ICG Fluorescence Imaging and Navigation Surgery , Springer , Tokyo , 2016

4. Heterocyclic polymethine dyes: synthesis, properties and applications , ed. L. Strekowski , Springer , Berlin/Heidelberg , 2008

5. Iodinated cyanine dyes: a new class of sensitisers for use in NIR activated photodynamic therapy (PDT)

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