Impact of dynamic sub-populations within grafted chains on the protein binding and colloidal stability of PEGylated nanoparticles
Author:
Affiliation:
1. Centre for BioNano Interactions
2. School of Chemistry
3. University College Dublin
4. Dublin
5. Republic of Ireland
6. School of Physics & Optometric & Clinical Sciences
7. Technological University Dublin
8. Dublin 8
9. Dublin 4
Abstract
NMR reveals three types of dynamic ethylene glycol units on PEG-grafted SiO2 nanoparticles, the distribution of which depends on chain length and coverage and affects colloidal stability and protein uptake.
Funder
Science Foundation Ireland
Publisher
Royal Society of Chemistry (RSC)
Subject
General Materials Science
Link
http://pubs.rsc.org/en/content/articlepdf/2021/NR/D0NR08294E
Reference67 articles.
1. Poly(ethylene oxide) Grafted to Silicon Surfaces: Grafting Density and Protein Adsorption
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4. Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers
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