Two consecutive aza-amino acids in peptides promote stable β-turn formation in water-Reference-Cited by-同舟云学术

Two consecutive aza-amino acids in peptides promote stable β-turn formation in water

Published:2022 Issue:43 Volume:20 Page:8430-8437
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shi Chenghui¹,Correia Isabelle²,Tonali Nicolo¹,Ongeri Sandrine¹^ORCID,Lequin Olivier²^ORCID

Affiliation:

1. Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France

2. Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Laboratoire des Biomolécules, 4 place Jussieu, 75252 Paris Cedex 05, France

Abstract

In contrast to peptides containing exclusively α-amino acids, the insertion of two consecutive aza-amino acids in tripeptides induces 10-membered beta-turn conformations in aqueous solution.

Funder

China Scholarship Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01225A

Reference37 articles.

1. Trends in peptide drug discovery

2. Orally Active Peptides: Is There a Magic Bullet?

3. Therapeutic peptides: Historical perspectives, current development trends, and future directions

4. Peptidomimetic toolbox for drug discovery

5. Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

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