Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor-Reference-Cited by-同舟云学术

Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor

Published:2019 Issue:36 Volume:10 Page:8428-8437
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Kailass Karishma¹²³⁴,Sadovski Oleg¹²³⁴,Capello Michela⁵⁶⁷⁸,Kang Ya'an⁹⁶⁷⁸,Fleming Jason B.¹⁰¹¹¹²⁸,Hanash Samir M.⁵⁶⁷⁸,Beharry Andrew A.¹²³⁴^ORCID

Affiliation:

1. Department of Chemical and Physical Sciences

2. University of Toronto Mississauga

3. Mississauga

4. Canada

5. Department of Clinical Cancer Prevention

6. The University of Texas MD Anderson Cancer Center

7. Houston

8. USA

9. Department of Surgical Oncology

10. Department of Gastrointestinal Oncology

11. H. Lee Moffitt Cancer Center

12. Tampa

Abstract

We report the development of a ratiometric fluorescent chemosensor that selectively measures human carboxylesterase 2 (hCES2) activity with application in pancreatic cancer patient-derived xenografts.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC00283A

Reference40 articles.

1. The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?

2. Human carboxylesterases: a comprehensive review

3. Human Carboxylesterase-2 Hydrolyzes the Prodrug of Gemcitabine (LY2334737) and Confers Prodrug Sensitivity to Cancer Cells

4. Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

5. Identification of Human Intestinal Carboxylesterase as the Primary Enzyme for Activation of a Doxazolidine Carbamate Prodrug

Cited by 40 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A rapidly metabolizable and enzyme-activated NIR fluorescent probe based on isophorone for imaging in vivo;Sensors and Actuators B: Chemical;2024-11

2. Near-infrared fluorescent probe based on carboxylesterase 2 and viscosity cascade response for early diagnosis of thyroid cancer;Sensors and Actuators B: Chemical;2024-08

3. Molecular insights on Eltrombopag: potential mitogen stimulants, angiogenesis, and therapeutic radioprotectant through TPO-R activation;Platelets;2024-06-04

4. An Expedient Approach to Access Phenalenones via Unconventional [1,2]-Phospha-Brook Rearrangement/Carbonyl Migration;The Journal of Organic Chemistry;2024-05-10

5. Rational Design of a Highly Sensitive Carboxylesterase Probe and Its Application in High-Throughput Screening for Uncovering Carboxylesterase Inhibitors;The Journal of Organic Chemistry;2024-05-08