Mechanistic role of nucleobases in self-cleavage catalysis of hairpin ribozyme at ambient versus high-pressure conditions
Author:
Affiliation:
1. Lehrstuhl für Theoretische Chemie
2. Ruhr-Universität Bochum
3. 44780 Bochum
4. Germany
Abstract
Extensive replica exchange simulations at ambient as well as high-pressure conditions provide mechanistic insights into the self-cleavage catalysis reaction of hairpin ribozyme.
Funder
Deutsche Forschungsgemeinschaft
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP03142H
Reference102 articles.
1. The chemical repertoire of natural ribozymes
2. The antiquity of RNA-based evolution
3. An unusual pH-independent and metal-ion-independent mechanism for hairpin ribozyme catalysis
4. Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations
5. Crystal structure of a hairpin ribozyme–inhibitor complex with implications for catalysis
Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Elucidating the Self-cleavage Dynamics of Hairpin Ribozyme by Mode-decomposed Infrared Spectroscopy;The Journal of Physical Chemistry Letters;2023-08-30
2. On the Adaptability of the Chemical Reaction of Hairpin Ribozyme to High Pressures;The Journal of Physical Chemistry Letters;2020-10-21
3. Deciphering the Self-Cleavage Reaction Mechanism of Hairpin Ribozyme;The Journal of Physical Chemistry B;2020-05-26
4. Nucleic Acid Catalysis under Potential Prebiotic Conditions;Chemistry – An Asian Journal;2019-12-09
5. Ribozyme Chemistry: To Be or Not To Be under High Pressure;Chemical Reviews;2019-12-05
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