A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces-Reference-Cited by-同舟云学术

A theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

Published:2023 Issue:1 Volume:19 Page:31-43
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Sadhu Raj Kumar¹^ORCID,Barger Sarah R.²,Penič Samo³,Iglič Aleš³^ORCID,Krendel Mira⁴^ORCID,Gauthier Nils C.⁵,Gov Nir S.¹^ORCID

Affiliation:

1. Department of Chemical and Biological Physics, Weizmann Institute of Science, Rehovot 7610001, Israel

2. Molecular, Cellular, Developmental Biology, Yale University, New Haven, USA

3. Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia

4. Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, USA

5. IFOM, FIRC Institute of Molecular Oncology, Milan, Italy

Abstract

We model the process of phagocytosis of rigid particles by a vesicle containing curved membrane-bound protein complexes, which recruit the protrusive force of actin polymerization, and facilitate engulfment by self-organizing at the phagocytic cup.

Funder

Gordon and Betty Moore Foundation

Israel Science Foundation

National Institute of General Medical Sciences

Howard Hughes Medical Institute

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SM/D2SM01152B

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