Synthesis of 2-aroylfuro[3,2-c]quinolines from quinolone-based chalcones and evaluation of their antioxidant and anticholinesterase activities

Abstract

A series of 2-aroylfuro[3,2-c]quinolines 2a–e was synthetized from quinolone-based chalcones 1a–e. When R = ortho-OH, an unexpected compound 3 was also obtained. Compounds, 2a and 2c, showed significant inhibition of acetylcholinesterase enzyme.