Controlling cellular distribution of drugs with permeability modifying moieties-Reference-Cited by-同舟云学术

Controlling cellular distribution of drugs with permeability modifying moieties

Published:2019 Issue:6 Volume:10 Page:974-984
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Richardson Paul L.¹²³^ORCID,Marin Violeta L.¹²³,Koeniger Stormy L.¹²³^ORCID,Baranczak Aleksandra¹²³,Wilsbacher Julie L.⁴⁵³^ORCID,Kovar Peter J.⁴⁵³,Bacon-Trusk Patricia E.⁴⁵³,Cheng Min⁴⁵³,Hopkins Todd A.⁴⁵³,Haman Sandra T.⁴⁵³,Vasudevan Anil¹²³^ORCID

Affiliation:

1. Drug Discovery Science and Technologies

2. North Chicago

3. USA

4. Discovery Oncology

5. AbbVie Inc.

Abstract

Anionic moieties can be used to control the cell-permeability of drugs and used to select the appropriate target identification method for phenotypic screening hits.

Funder

AbbVie

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00412A

Reference49 articles.

1. Innovation in the pharmaceutical industry: New estimates of R&D costs

2. Phenotypic vs. Target-Based Drug Discovery for First-in-Class Medicines

3. Applications of chemogenomic library screening in drug discovery