Cross-linking of aromatic phenolate groups by cytochrome P450 enzymes: a model for the biosynthesis of vancomycin by OxyB-Reference-Cited by-同舟云学术

Cross-linking of aromatic phenolate groups by cytochrome P450 enzymes: a model for the biosynthesis of vancomycin by OxyB

Published:2020 Issue:24 Volume:18 Page:4610-4618
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ali Hafiz Saqib¹²³⁴⁵^ORCID,Henchman Richard H.¹²³⁴⁵^ORCID,de Visser Sam P.¹²³⁴⁶^ORCID

Affiliation:

1. Manchester Institute of Biotechnology

2. The University of Manchester

3. Manchester M1 7DN

4. UK

5. Department of Chemistry

6. Department of Chemical Engineering and Analytical Science

Abstract

Aromatic cross-linking by cytochrome P450 enzymes was studied computationally. P450 Compound I rapidly abstracts two weak phenolic H-atoms that link up via a rate-determining C–O bond formation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/OB/D0OB01023E

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