Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducer-Reference-Cited by-同舟云学术

Synthesis and conformational studies of a stable peptidomimetic β-hairpin based on a bifunctional diketopiperazine turn inducer

Published:2015 Issue:5 Volume:39 Page:3250-3258
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Vahdati Leila¹²³⁴⁵,Fanelli Roberto¹²³⁴,Bernadat Guillaume⁵⁶⁷⁸⁹,Correia Isabelle¹⁰¹¹¹²¹³¹⁴,Lequin Olivier¹⁰¹¹¹²¹³¹⁴,Ongeri Sandrine⁵⁶⁷⁸⁹^ORCID,Piarulli Umberto¹²³⁴

Affiliation:

1. Università degli Studi dell'Insubria

2. Dipartimento di Scienza e Alta Tecnologia

3. I-22100 Como

4. Italy

5. Molécules Fluorées et Chimie Médicinale

6. BioCIS UMR-CNRS 8076

7. LabEx LERMIT

8. Université Paris-Sud

9. Faculté de Pharmacie

10. Sorbonne Universités – UPMC Univ Paris 06

11. Ecole Normale Supérieure – PSL Research University

12. CNRS UMR 7203 LBM

13. 75252 Paris Cedex 05

14. France

Abstract

A new β-hairpin mimic foldamer based on the assembly of a reverse turn inducer, a peptidomimetic strand, and a tetrapeptide sequence was prepared, and its conformation in solution was assessed by NMR and computational investigations.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/NJ/C4NJ01437E

Reference50 articles.

1. α-Helix mimetics: Outwards and upwards

2. A Field Guide to Foldamers

3. The Supramolecular Chemistry of β-Sheets

4. Protein–protein interaction through β-strand addition

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