Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, <i>in vitro</i> and <i>in vivo</i> anti-diabetic evaluation-Reference-Cited by-同舟云学术

Thiazolidine-2,4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation

Published:2024 Issue:8 Volume:15 Page:2826-2854
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Singh Gurpreet¹²^ORCID,Singh Rajveer³,Monga Vikramdeep⁴^ORCID,Mehan Sidharth⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, ISF College of Pharmacy, (Affiliated to IK Gujral Punjab Technical University, Kapurthala), GT Road, Ghal Kalan, Moga-142001, Punjab, India

2. Research Scholar, IK Gujral Punjab Technical University, Kapurthala, Punjab, India

3. Department of Pharmacognosy, ISF College of Pharmacy, GT Road, Ghal Kalan, Moga, Punjab, India

4. Drug Design and Molecular Synthesis Laboratory, Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, VPO-Ghudda, Bathinda, Punjab, India

5. Department of Pharmacology, ISF College of Pharmacy, (Affiliated to IK Gujral Punjab Technical University, Kapurthala), GT Road, Ghal Kalan, Moga, Punjab, India

Abstract

Synthesis and biological evaluation of TZD-based hybrids.

Funder

Science and Engineering Research Board

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00199K

Reference72 articles.

1. Alpha‐amylase as molecular target for treatment of diabetes mellitus: A comprehensive review

2. Burden of type 1 and type 2 diabetes and high fasting plasma glucose in Europe, 1990-2019: a comprehensive analysis from the global burden of disease study 2019

3. Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice