Novel flexible biphenyl <i>Pf</i>DHFR inhibitors with improved antimalarial activity-Reference-Cited by-同舟云学术

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Novel flexible biphenyl PfDHFR inhibitors with improved antimalarial activity

Published:2024 Issue:7 Volume:15 Page:2496-2507
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Decharuangsilp Sasithorn¹^ORCID,Arwon Uthai¹^ORCID,Sooksai Nawarat¹^ORCID,Rattanajak Roonglawan¹^ORCID,Saeyang Thanaya¹^ORCID,Vitsupakorn Danoo¹^ORCID,Vanichtanankul Jarunee¹^ORCID,Yuthavong Yongyuth¹^ORCID,Kamchonwongpaisan Sumalee¹^ORCID,Hoarau Marie¹^ORCID

Affiliation:

1. National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand

Abstract

Increased compound flexibility increases access to the cellular target.

Funder

National Science and Technology Development Agency

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00197D

Reference20 articles.

1. World malaria report 2022 , World Health Organization , Geneva , 2022 , Licence: CC BY-NC-SA 3.0 IGO, https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2022

2. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

3. First‐in‐human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection

4. Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study

5. New insights into antimalarial chemopreventive activity of antifolates

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